I have that type of Glock in question and I reload for it, I'm willing to bet the case has been overused and got thin, also the Glock barrels do leave a portion of the case exposed that can case a rupture especially if its a hot load. I did buy an aftermarket barrel that drops in and uses the .45 case but is necked down to become a .400 CORBON.
A .45 recoil isnt bad really but I use the Glock 10mm as my personal protection. My favorite though is the single stack SIG P220 .45 very nice built.
I have several 9mm but recently I have felt the need to have more stopping power and more rounds aviable like double stack mags. Hi cap .45 mags are a bit wide for a small handed person and having only 8 rounds is just not safe insurance especially if you have crazed multiple assailants.
best round for a woman, .357 SIG for a guy that can handle recoil a good 10mm. Glocks are good cause they are ready to fire right then and are simple simple firearms.
Buying a .50AE or anything else of the super macho handguns is asking for big trouble, the rounds are hard to manage unless you have the strength, the round which if you miss your target and you most likely will, have tremendous collaterial damage such as penetrating walls and such.
My husband has a couple of Glocks, but I prefer a revolver. You're right about 357 for the ladies. I carry a Smith lg frame 357 with Crimson Trace Laser and my Valentine present about 5 years ago was a Smith Trail Boss, which I love! I have had several automatics over the years and experienced a few jams. Hubby says Glocks have never jammed on him, but I wouldn't want to take the chance, if my safety depended on it....It must be a "female thing" LOL
The most painful handgun I ever shot was a TC custom by J.D.Jones. A 444 Marlin with magna porting. NEVER again :) My TC is a 7mm Int R and that's just fine, but MR.Proud Conservative thought I might like the 444 for..DUH
You forgot about the fun factor associated with the big guns. A friend plinks with full house loads in all of his Freedom Arms guns. His standard targets are clay birds on a dirt bank at 60 yards away. .454's, .475's or .50's it doesn't make any difference. He hits with all of them.