I have a Sig Pro 2340 with a .357 Sig barrel in it. I have both barrels, but prefer the 357.
The only real downsides are that they 12 round mags are a little harder to come by than say Glocks. You can get them, but most (if not all) will have the AWB 'leo only' stamps on them.
Also, the plastic finishing is easy to mark up. I tried cleaning it with Q-tips once, and it basically wiped away some of the stipled finish on the frame.
Other than that, I love it. Never had a misfire at all, very accurate.
They concluded that a hit in the torso from a .40 supersonic rounbd had a 100% probability of incapaciting a man, while for the .40 subsonic and .45 rounds it was 90% .
I don't remember precisely what the number was for the 9mm, but I think it was slightly less than 80%.