Actually MANPADS have a surpisingly small chance of taking down a large airliner.
I've always wondered about that. A 747, for instance, is a damn big airplane and, even if a Stinger managed to take out one engine, so what?
I don't know that commercial airliners have self-sealing tanks and other protections against sharpy, pointy, blowie-up things. Fuel going up might be problem.