[tallhappy]

Try to duck with sarcasm, fine, but how was the structure of the ribosome determined?

How might you determine, for example, the mechanism of action of an antibiotic via ribosomal RNA sequence comparision?

[Right Wing Professor]

Try to duck with sarcasm, fine, but how was the structure of the ribosome determined?

X ray. Paper came out a couple of years ago.

How might you determine, for example, the mechanism of action of an antibiotic via ribosomal RNA sequence comparision

That's not how I would do it.

Antibiotics directed at ribosomes are pretty broad spectrum - indicating the ribosome structure and function is highly conserved.