[Right Wing Professor]

I am addressing how sequences, genomes included, do make sense outside of an evolutionary perspective and their analysis is of value even without evolutionary considerations.

I suppose it depends on what you mean by 'making sense'. Sure, you can identify streptomycin binding sites in bacterial ribosomes, and look at homologous sites in mitochondrial ribosomes to see if mutations at those sites are associate with deafness; but without an explanation of the homology, which evolution provides, any deductions you make depend on a fortuitous accident.

[tallhappy]

Sure, you can identify streptomycin binding sites in bacterial ribosomes, and look at homologous sites in mitochondrial ribosomes to see if mutations at those sites are associate with deafness

I'd consider that "making sense".