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To: Mom MD; Pharmboy

Here are some references. If you click on the link, you will find more there on food allergy and aspirin.

1. Food anaphylaxis induced by aspirin. Allerg Immunol (Paris). 2001
Mar;33(3):147-9.

2. [A clinical case of 13 years old boy of aspirin-induced asthma with food
allergy] Arerugi. 2000 Nov;49(11):1104-7. Review.

3. Dramatic augmentation of a food allergy by acetylsalicylic acid. J
Allergy Clin Immunol. 2000 Apr;105(4):844. .

4. Aspirin enhances the induction of type I allergic symptoms when combined
with food and exercise in patients with food-dependent exercise-induced
anaphylaxis. Br J Dermatol. 2001 Aug;145(2):336-9. (full text should be free
online check link below)

We examined the effect of aspirin as a substitute for exercise in inducing
urticaria/anaphylaxis in three patients with food-dependent exercise-induced
anaphylaxis (FDEIA). Two of the patients had specific IgE antibodies to
wheat and the other had antibodies to shrimp. Administration of aspirin
before ingestion of food allergens induced urticaria in one patient and
urticaria and hypotension in another, while aspirin alone or food alone
elicited no response. The third patient developed urticaria only when he
took all three items, i.e. aspirin, food and additional exercise, whereas
provocation with any one or or two of these did not induce any symptoms.
These findings suggest that aspirin upregulates type I allergic responses to
food in patients with FDEIA, and further shows that aspirin synergizes with
exercise to provoke symptoms of FDEIA. This is the first report of a
synergistic effect of aspirin in inducing urticaria/anaphylaxis, which was
confirmed using challenge tests in patients with FDEIA.

http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2133.2001.04329.x


106 posted on 11/26/2005 3:03:31 PM PST by freespirited
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To: freespirited; Mom MD

Aspirin has not been used for kids since the 1970s because of Reye's Syndrome. Not a factor. For the increase of childhood asthma, they have been looking at cockroaches.


114 posted on 11/26/2005 3:11:49 PM PST by Pharmboy (The stone age didn't end because they ran out of stones.)
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To: freespirited; Mom MD

Actually, one theory gaining some adherents is that the absence of aspirin use in kids is the CAUSE of the increase in asthma:

Ann Allergy Asthma Immunol. 1998 Oct;81(4):347-51. Related Articles, Links


Hypothesis: decreased use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma.

Varner AE, Busse WW, Lemanske RF Jr.

Allergy Diagnostic, Beachwood, Ohio 44122, USA.

BACKGROUND: The prevalence of asthma, atopic eczema, and allergic rhinitis has increased over the last three decades in Western countries. Speculation on the causes of this trend have focused on changes in environmental factors. We hypothesize that the decreased use of aspirin in favor of acetaminophen, due to the association of aspirin with Reye's syndrome during febrile respiratory infections, may be contributing to these trends in the United States. DATA SOURCES: A detailed literature search was conducted utilizing Medline. Studies considered relevant and important involving both humans and animals in English language were used. HYPOTHESIS: In the United States, the documented prevalence of childhood asthma has increased since 1970, but the rate of this increase accelerated upward beginning in the early 1980s when the use of pediatric aspirin decreased. During the resolution of common respiratory viral infections, prostaglandin E2 (PGE2) is produced through the actions of cyclooxygenase-2 (COX-2). Aspirin, but not acetaminophen, inhibits COX-2 activity. As PGE2 promotes TH2 and inhibits THI type cytokine generation, we hypothesize that the decreased use of aspirin may be a factor in facilitating allergic sensitization and asthma by augmenting the relative TH1/TH2 cytokine imbalance in genetically predisposed children. CONCLUSION: We have presented an hypothesis based upon epidemiologic trends, known biologic effects of cytokines and PGE2 on allergic sensitization, and a potentially relevant pharmacologic effect of aspirin to explain a component of the increasing prevalence of childhood asthma in the United States. We suggest this theory be examined further in animal models as well as in other countries where the prevalence of childhood asthma is increasing.


126 posted on 11/26/2005 3:20:42 PM PST by Pharmboy (The stone age didn't end because they ran out of stones.)
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