After that time the Indians had to make deals with the Europeans since they could no longer mount a serious military presence.
It's worth noting that the war between the Iriquois and Mohican Indians that had been going on for 300+ years ENDED due to the absence of Mohican warriors. They were adopted by the Oneida. You can find them today at lake Winebago ~ they are the Munsee Band.
Disease did the job.