Hey, that's what the .455 Webley is for! Truly a Blunt Instrument in every sense of the word.
But anybody who hunts dangerous game with anything smaller than a .348 Winchester or .375 Holland & Holland is not much brighter than that idiot who tried to talk to the grizzly bears and got eaten for his pains.
At one point, when for some reason I like the idea of ridiculous amounts of recoil in a handgun, I was going to get myself a T/C Contender. This is years ago... At the time, I was either going to get it in .444 Marlin, 45-70, or (what was considered the world's most powerful handgun cartridge at that time), the .375JDJ. I just wanted to be sure that I'd never be bothered by varmints like cape buffalo in my back yard. You never know, one might show up! And just in case, it always pays to be prepared! I had the chance to meet a guy who happened to have a T/C in .444 Marlin, and one shot from that helped me decide that while interesting, I really didn't need to submit myself to that sort of abuse on a regular basis!
Still, the .375JDJ has been used to take all big game in North America, as well as Africa! Although I can't imagine shooting an elephant or cape buffalo with a bullet or 270 or 300 grains. Anything less than 500 grains just seems "weak."
Mark