the NHC has gotten several thousand letters per year, every year, for decades suggesting this.
Short answer is that it would have no effect other than to turn the rain from the storm radioactive. A hurricane would laugh at even the largest nukes.
The only plausible means of human modification is to spread a vast slick of an oil-like subtance over tens of thousands of square miles of ocean that would prevent evaporation, in the path of a storm.
Makes for a good movie of the week, though. I can see it now - the voodoo high priestess made a mistake with one of her evil spells, and sent the hurricane to NO. Bruce Willis volunteers for the suicide mission to save the gulf.
what about help from Aquaman...sorry saw too many Saturday morning "SuperFriends" growing up...