Multiple issues here. First, the greatest danger to any house from wind is roof failure from lifting off of the house. After that, the rest of the house collapses pretty easily. Hurrican clips tie the roof down and help prevent failure there.
Second, a house on stilts would generate some kind of lift from air passing over the roof and under the house, just like a wing. This is probably the greatest danger from wind. Best way to fix that is to disrupt laminar flow over the house. Chimneys and other protrusions can take care of that on the roof, and lattice across the legs can help underneath.
By far, though, the greatest danger to any structure that is not a mobile home is still from flooding, and not wind.
...but I did stay at a Holiday Inn Express
:') I was wondering how you would keep the air from lifting it off the pillars. Around here many have garages underneath.