Debt is not all the same debt. If you can't pay for your credit card purchases, they can't take your home.
More disturbing is the interest only loans folks are taking. As the market cools and interest rates rise, living paycheck to paycheck is going to get tougher and tougher.
I like the advice of another poster - have one home you can fall back in if need be.
Not directly, but if someone is in over his/her head with debt, their home will be at risk via a judgment recorded against their property. Furthermore, it is unbelievable that people can't see the wisdom of eliminating debt as an end unto itself.