Distance will not be measured in miles but in time. Time management is essential to business. The inner solar system presents distances of two to eighteen months depending how things line up. Improved propulsion should cut the distance as space development proceeds and the bottom line should reflect that improvement.
Development of the distant resources of the solar system will become practical in a business sense when the distances are reduced to months rather than years and decades. During all this development, the presence of humans in interplanetary space will continue to be uncommon as that would cut into the bottom line substantially. The main presence of humans would be the bases on the moon. Secondary bases could be on Mars. All these bases would initially be of a scientific nature, there being no reason to use manned bases in either place for resource handling.
But there is no reason to ship anything anywhere, unless people are there!
In today's inner cities, the resources are available. The demand is there. And the profit potential is high, but the major corporations don't go there because they are risk-averse.
Only the small, tight-knit family grocer is willing to take the risk, and only because his family backs him.
Resources are where you find them. In Coober-Pedy, the mines became the homes, and the homes are the mines. I would suspect the asteroids will be similar.
A hole in a rock may not appeal to an employee, but it might be just the thing for a family which is society-averse, or even a couple of individuals.