In 1811 the area was sparsely populated. Today St. Louis and Memphis would receive damage from a big scale quake and St. Louis has no building codes concerning earthquakes.
Just an aside; earthquake damage to structures varies. If you build on rock, you'll shake and lose all kinds of stuff that falls and breaks but the structure should survive. If you build on soil (floodplains, deep soil areas), the structure will be racked if not split up or collapsed. Seismic waves through deep soil areas are very destructive.