There may be a reason that generations have been affected starting with the maternal grandmother.
http://seattlepi.nwsource.com/national/227013_toxics03.html
Thanks, FRiend, for #15, I'll pass that link on.
Or a much simpler one, if auto-immune diseases are infectious, and slow-growing, then they might be passed from mother to child and the transmission not noticed due to the time lag before symptoms appear.