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I was trying to supply something from the better minds of our times. Try this discussion of simple heating, not even a chemical reaction. http://64.233.161.104/search?q=cache:6DWqpXmT8cEJ:fie.engrng.pitt.edu/eng12/Author/final/132.doc+combustion+mass+to+energy+conversion+e%3Dmc2&hl=en&ie=UTF-8 "Now we can reserve the relation E=mc2 and say that an increase of E in the amount of energy must be accompanied by an increase of E/c2 in the mass. It is very easy to supply energy to mass—for instance heat it by ten degrees. So why not measure the mass increase connected with this change? It is nearly impossible. Keep in mind that the speed of light is equal to three hundred million meters per second. Thus in calculating the mass increase, one would divide the energy by the speed of light squared. When such a big number is in the denominator, the quotient (or answer to division problem) tends to be very small. Thus an increase in mass does occur, but it is too small to be measured directly; even with the most sensitive balance."