Since I mentioned reactions I thought it was clear, but...
delG = delH -T*delS
The enthalpy, or heat of reaction is larger than T*delS and what drives "the signal".
Sufficient delH also can reduce S...
S in that equation is the system entropy. There is also the entropy of the surroundings. The entropy change in the surroundings is -qrev/T, and since the reversible heat at constant pressure equals the enthalpy change Delta H, DeltaH = -T DeltaSsurr. So DeltaG = -T(Ssurr+Ssys)