"Dust" PLUS something else makes all systems in nature, living and non-living! Or so it seems to me.
Matter doesn't deserve a "bum rap." It, plus space and time, are the productions of the Big Bang. We like matter -- without it, nothing would exist. Its "spiritual complement," if I might put it that way, is what makes it to be the various given things of nature "in their serried ranks." And so I think matter does merge "seamlessly with the spiritual."
I note your remark that "spirit" is the name we give to that which we do not yet understand. I think that is a true insight, js1138. And so it seems to me that people who break out in a rash on the mere hearing of the word "spiritual" risk falling into a condition, not only of spiritual, but also of intellectual closure. This would not seem to portend much good for the evolution of science. JMHO FWIW.