I just ran my Webroot Spy sweeper and it didn't find any spyware on my computer.
I run Norton Internet Security firewall and intrusion detection, Norton Antivirus (all the time, automatically), SpySweeper, SpyBot Search & Destroy, Spyware Blaster, AdAware, Panda ActiveScan AND TrendMicro Housecall (weekly)...and none of them found anything, but I was still having odd things happen, so I tried PestPatrol. It found two RAT trojans, a backdoor trojan, keystroke loggers, seven or eight dialers, and OODLES of spyware/adware. I wouldn't rest comfortably knowing that SpySweeper was keeping me clean.
Some files had embedded in my vacation photos, some in spreadsheets, very very very odd stuff.