Solution: spend $40 on Norton Internet Security/Anti-Virus. Or McAfee. No more popups, no more viruses.
Norton and McAfee will protect you from viruses and hackers, but not from spyware. A popup blocker just blocks the popups, but if you've got some malevalent program causing them, (Gator, Coolsearch, BonziBuddy, etc...), you don't just want to get rid of the popup, you want to get rid of what caused it.