Love Adblock with 3 entries *doubleclick* */realmedia/ads/* and *fastclick* I already block 90%+ of the ads I used to see.
You can do the same with a good Hosts file. It will block every pop up ad domain on the Web.
Add http://*.fastclick.net/* to kill even more.
Thanks for that realmedia folder tip. In looking at my list I notice I have that folder in several specific sites blocked, now it's just blocked for all sites.