I have a couple of revolvers, but I still like my 1911A1 and my Combat Commander the best. I have a .38 Super on a 1911A1 frame and a Lightweight Commander as well.
I know a revolver is the "original point and click interface," and very reliable, but the Colt autos are natural pointers for me and fit my hand perfectly (I have Pachmayer grips on all of them). I don't have a particularly small hand, but revolvers just hit me wrong, especially with the rubber grips, and I don't feel as comfortable with them as the .45s.
I guess it's just a case of "to each his own, as the lady said when she kissed the cow." :-D