Excuse me but do you know that different loads are available for every caliber? Are you aware that cops & feds are legally prohibited from using anything but 'ball ammo' (NO hollow points or 'hot' loads).
Also, I have a .38 Colt Detective Special & back in the mid '70's I used to shoot 158 grain Super Vels in it. And I'll tell you what, you wouldn't laugh long if shot with one. When I took it to an indoor range, it sounded like a frickin cannon - everyone would come to see what the heck I was firing. I got tipped to the 'benefits' of the Super Vel by a Chicago PD undercover Narc. And yes he was 'breaking the law' but his life depended on his ammo.
Also, do you know that the first practical revolver, the Colt Patterson wasn't made until 1837. Do you know that the Colt Single Action Army (aka Peacemaker) wasn't even made until 1873 & Colt's 1st DA the Lightening wasn't made until 1877. Do you know that in the 'old west', the most popular caliber was actually the .44-40, not the 45 Colt. However, a .45 caliber SAA could fire the shorter .44-40, but not vise-versa.
Which BTW, reminds me of poor ole Lester Moore who's buried in Boot Hill in Tombstone, AZ:
Les Moore
HERE LIES
Lester Moore
Four slugs
From A .44
No Les
No More
BTW, until he 'died' in 1876 Wild Bill Hickok still used .36 caliber 1851 Navy Colts - cap & ball revolvers. Oh and for what it's worth, the Winchester was NEVER chambered in .45 Colt, but mostly 44-40.
He was also a former Texas Ranger and Industrial League baseball umpire (the latter profession having an even shorter life expectancy than being a Ranger.) Needless to say, there was beautiful, serene, uninterrupted order in his court.
Bingo!
That way one only needed to carry one type of ammo to feed both his side arm and long arm.