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To: Nebullis
You may have missed the greater sequence homology at the level where evolutionary distance is less.

I merely look at the evidence presented and make judgements on the things I see, not on the things someone else has privy to. You have the great opportunity to present elucidation, presently you are not. My question was fairly simple, are not the insects I mentioned at the same level according to diagram B as presented. Another question from someone who relies on good answers from others who should know, what is considered the repressor region in the sequences shown? Is it the red region? The Blue? or the whole sequence as given? Or is it one of the lined regions?

74 posted on 02/08/2002 5:47:57 PM PST by AndrewC
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To: AndrewC
A legend would probably be helpful. Referring to this figure :

A repression domain containing poly-alanine evolved in the insect lineage. a, An alignment of part of helix 3 of the homeodomains and C-terminal amino-acid sequences from several Ubx orthologues. Red shading indicates residues conserved among the homeodomains and Ubd-A peptides. Identical amino acids are designated by black letters within the shading, whereas those similar in function are indicated by white letters. Amino acids identical to those in DUbx C-terminal to the Ubd-A peptide and shared by at least three sequences are shaded blue; those similar in function are shaded green. Sequence gaps are shown as dashes, and translation stops are asterisks. An ellipsis (...) indicates additional amino acids not shown. Note the presence of the poly-alanine motif in all insects but not in collembolan or other arthropod Ubx orthologues. b, The distribution of the poly-alanine domain is mapped onto an arthropod phylogeny (taken from ref. 30). The repression domain arose in the insect lineage after its split from the more basal hexapods. In a, the two-letter species designations used to name Ubx orthologues designate the following animals: Dm, Drosophila melanogaster (Diptera); Ag, Anopholes gambiae (Diptera); Jc, Junonia coenia (Lepidoptera); Ms, Manduca sexta (Lepidoptera); Tc, Tribolium castaneum (Coleoptera); Fc, Folsomia candida (Collembola); Er, Ethmostigmus rubripes (Myriapoda); Cs, Cupiennius salei (a chelicerate with two Ubx orthologues); Af, Artemia franciscana (Crustacea); Ak, Acanthokara kaputensis (Onychophora).

75 posted on 02/08/2002 7:43:30 PM PST by Nebullis
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