[Rudder]

For evolutionary processes, "random" does not mean that mutational events all occur with equal probability. Genomic mutational "hotspots" and epigenetic (environmentally) directed events are well described.

I agree. That's the gist of one of my posts.

[Nebullis]

Yes. Drive and constraint are pervasive and all except the most ardent neo-darwinist accepts that they contribute to direction in evolution.