However, Sinequan, an antidepressant/tranquilizer, must be prescribed, and is legal. The resemblance of the molecular structures, at least the dibenzopyran skeleton is, to say the least, curious.
The cultivation and dispensing of Henbane, Hyoscyamus niger, is not Approved. However, the sale of the belladona alkaloid Hyoscyamine sulfate in Contac(TM) cold capsules, is OK.
Many things in Nature, when isolated, become legal and acceptable because they will produce reproducible results.
Some examples include willow bark (Aspirin), Rauwolfia serpentina (digitalis), Nux vomica (Strychnine), Goldthread root (Brucine), and probably hundreds of others.
There are several "Problems" with cannabis:
1: The mixtures of THC Isomers and other active components is widely variable with regard to strain, location of growth, and other conditions. If _one_ compound could be isolated and rigorously FDA Tested and proven safe and effective, there would not be this dispute. For example, let us say that we specifically mean one isomer, more specifically, 1-Hydroxy, 6,6,9-trimethyl dibenzopyran. The problem is that it does not affect different people the same way... And other people will react differently some times.
I have gotten some things approved by the FDA. It is neither cheap nor fun, but really, there are reasons for the cautions- Thalidomide comes to mind.
2: The stuff grows like a weed. Well, in some places it IS a weed. How can anyone base a monopoly on this? :-)
Like many I do not exactly consider SKF, Merk, etc. and others to be entirely altruistic organizations.
3: The medicine is too much fun and too uncontrollable- Despite its use for milennia. But whenever one sees polycyclic molecules nowadays, in the back of the mind, the word "Carcinogen Suspect" appears. If someone wishes to smoke their silage on their own, I can see where that is none of my business.
But if I am a stockholder in a drug company, I am not sure I want to see this stuff prescribed. I believe I read the half life of THC's in the body is 70+ days. If so, this is asking a lot of the liver, and it means that Mister Liver is not doing that well clearing it.
so not only are the drug companies a bit unwilling to invest a lot in a technology 5,000 years old, they are also very risk-shy. In old societies where cannabis was used a lot, what was the life expectancy of the people? Did they live long enough to develop cancer?
Let's watch what happens when all the '60's people, myself included, make it to Rest Home Age.
I spend too much time visiting those homes. Cancer is no fun, but I think I would choose it over wasting away not knowing who or where or when I was. Same to be said for a heart attack.
Thanks for the informative post. If I may interject, I believe that the reason it has such a long biological half-life is because of its solubility in fats and oils, and thus its enormous apparent volume of distribution. The liver has no problem eliminating it, but if it is sequestered in adipose tissue it will not even reach the hepatocytes, much less be excreted.
-ccm
I was just going to twist a doob, and share it with a friend!!
You make it sound so clinical!!