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To: corkoman
I agree in principal; I am not a researcher (and don't play one on TV), but I have read that the reason researchers inject drugs is so that they know more precisely what the blood levels are, without having to worry about the many factors that can change gut or stomach absorption, which can vary from animal to animal and day to day.

If they report serum, brain, or blood levels in the final and normalize the results to that, then I'd be less inclined to reject the results. I have not read the report itself, anybody got a link?

DMT and Salvinorin-A are ineffective when eaten, and Morpheine Sulphate does not work when insufflated, so you do need to worry about how you deliver.
43 posted on 09/12/2003 1:17:53 PM PDT by DBrow
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To: DBrow
you are correct about the value of injecting a test material - the variability of absorption is a bother. But for a safety study to have external validity its best to match the dosing behaviour of the humans.

Did you mean to insufflated- you CAN snort it but it just runs down the throat and you swallow it and its absorbed in the gut. Not the best way to deliver it as it is heavily cleared by the liver.

45 posted on 09/12/2003 1:29:00 PM PDT by corkoman (did someone say cheese?)
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