Much of this is already solved. Zebras, for example, don't know any traffic laws but seem to get from A to B just fine. Cats and owls can see in the dark. Cheetahs can run in excess of 60 mph and other animals can run in the 40s for exteneded periods easily. Camels, horses, elephants, donkeys, mules etc can all carry large amounts of cargo. It doesn't matter if it roams away when "parked" as long as it comes quickly when called. The computer would handle the GPS, navigation, internet and other functions. No need to run on pavement when a mountain or an open field look the same to the creature as a long flat road. Horses eat a fair amount when you're not using them too.
Keep in mind too- this is a flight of fancy- ie imagination.
Plus, even a car needs shoing regularly.
Or is it! Come on they are already cloning endangered spieces. To take a science for the benifit of mankind would help the whole world. They do it with our food now.
Put me a butter and salt flavor in that iodine rice for me.