Horses can out run bison today.
In short bursts. I *think* a bison can run a horse into the ground in the long haul.
The difference between being a sprinter and a marathon runner. Perhaps this difference in "wind" goes with an ability to surive a lower oxygen level.
That's three testable hypothesis. Do bison roam the hills? Can a bison out marathon a horse? -and- Can marathoners get by with less oxygen than sprinters?
Humans have more endurance than any mammal alive.