I think so, too, without a doubt. Even Hamilton, great "centralizer" that he was, acknowledged as much in The Federalist.
A government that de facto expunges the Constitution is illegitimate on its face; for it is usurping the sovereignty of the people, which is the ultimate foundation of the Constitution, and the political order premised on it.
Should the government so exceed its warrant from the people (and their posterity, of and for whom We the People so clearly spoke in the Preamble) as to do such a thing, the question then becomes a rather thorny one: The government has the de facto AND de jure monopoly of force (except that teeny little bit of it preserved to the people by the Second Amendment).
Before anyone opens that can of worms, I think we ought to get some justices impeached first.