[PistolPaknMama]

more recently Downs Syndrome

I don't think that is that recent either. My 24 year old nephew is Downs and I tried to find info on this not long after he was born, knowing nothing about it at all. I read way back then that it was link to vitamin B deficiency

[Black Agnes]

They've actually narrowed down the genetic pathway responsible they think. What's interesting is the correlation between maternal (and to some extent paternal) age and Downs is also found between age and blood homocysteine levels. The thought is that older mothers risk of Downs could be attenuated with proper supplements. Which would be wonderful. (nothing against your nephew, i'm sure he's a great kid, most Downs kids are).