Losers will be people who sit on their fat asses, who think they're entitled to a high-paying factory job with a high school diploma. Winners will be people who are willing to work hard and learn new skills in changing times.
Economic growth is not a zero-sum game, with people fighting over a share of the pie; the pie grows with economic growth, something most isolationist, protectionist, anti-immigrant folks are ignorant of. Before Adam Smith's "The Wealth of Nations", people thought it was a zero-sum game, but he was a LONG time ago and it's about time people caught up to the value of free trade and population growth.