The 22/25 are a compromise in carry package, certainly not in caliber choice. The 25 starts to come into a better cartridge, but only with specialized ammo....Glasers. The 380 is an ok cartridge, but if you are looking at a package that small, there are many good 38 Special revolvers in the same size and even less weight with Titanium available. And you get a more effective cartridge.
Have you seen this new pistol by Keltec yet? American made also.
KEL-TEC P-3AT PISTOL INTRODUCTION
The P-3AT is a semi-automatic, locked breech pistol, chambered for the .380 Auto cartridge. It has been developed from our highly successful P-32 pistol with negligible increase in weight and size. The slidestop has been eliminated and the magazine capacity reduced to 6 rounds due to the larger cartridge.
Technical Specifications
Caliber: .380 AUTO
Weight unloaded: 7.2 oz
Loaded magazine: 2.8 oz
Length: 5.2"
Height: 3.5"
Width: .77"
Sight radius: 3.8"
Muzzle energy max: 250 ftlbs
Capacity: 6+1 rounds
Trigger pull: 5 lbs