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In many ways I agree with your very pessimistic evaluation of the role fusion inhibitors have played in healing.

However the science is sound. We know that like a lock needing two separate keys, once both sites on gp120 are bound by CD4 and one of the coreceptors, gp120 flips back out of the way, exposing the virus' previously hidden harpoon molecule, gp41. gp41 is then free to pierce the cell and reel it in close enough to allow virus-cell fusion. And no matter how much corporate greed or our personal faults as scientists and researchers have failed the ill and hurting - it is right that we try to stop this terrible binding (fusion).

I would urge you to moderate your position and look at some of the second generation FI's being developed.

Dr. Harrison of Harvard's Children's Hospital is working very hard to inhibit fusion in the dengue virus.

While it is true that we have all fallen short of the Glory, the fight is noble and most of the warriors are among the finest men and women I have ever known.

Sure.

I think simple vaccination would be much more effective for SARS.

Why not address the flu first and foremost using FI? By far more is known about the fusion mechanism for that virus and it is a disease people get all the time.