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To: Alamo-Girl
I've seen Pax-6 described both as a regulatory gene and a master control gene.

Master control genes are regulatory genes.

Why would they overwhelming mutate, randomly, in the same way?

That's a good question and open for exploration. It's a highly adaptive direction to mutate, and other mutations may be very deleterious, that is, evolutionary options may be limited. Some suggest horizontal gene transfer in the same way that bacteria share antibiotic resistance genes. We don't know yet, but there are quite a number of people doing research in this area.

Sounds more like "pre programmed adaptation capability" to me...

What sort of evidence is there for "pre programmed adapation capability"? This front-loading idea is a favorite of IDists, but what is a plausible scenario for it? How does it work at the molecular level?

186 posted on 06/17/2003 8:31:23 AM PDT by Nebullis
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To: Nebullis
Thank you so much for your post!

We don't know yet, but there are quite a number of people doing research in this area.

I am anxious to stay on top of progress in this area of research. Do you have an internet location to pick up interdisciplinary work in that area?

What sort of evidence is there for "pre programmed adapation capability"? This front-loading idea is a favorite of IDists, but what is a plausible scenario for it? How does it work at the molecular level?

I have paid no particular attention to ID publications concerning microbiology, my interest lies in the mathematics, physics and information theory. Moreover, my adventures in biology have been at your suggestion and by your leads. Naturally, I followed the math/physics/information theory legs.

Getting back to the question at hand though. The evidence of "pre programmed adaptation capability" is in the research on Pax-6.

In support of evolution theory, the capability for eyeness may have been "built in" to the common ancestor by happenstance and passed along to all descendants. This would do injury to the random mutation pillar, but leaves the rest of evolution theory untouched.

In support of intelligent design, the capability would be endowed as an adaptation building block to all primary life forms. And from there it would be passed on as the species evolve. The difference between this and prior is a matter of causation, a mathy subject.

In support of creationism, the capability would be endowed as an adaptation building block to all primary life forms by special creation without evolution at all.

Just my two cents…

188 posted on 06/17/2003 8:55:32 AM PDT by Alamo-Girl
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To: Nebullis; Alamo-Girl
What sort of evidence is there for "pre programmed adapation capability"?

The Hox genes, all of them:

What do humans have in common with worms, flies and rodents? If you said, "not much," you're right. But not as "right" as you might think. During the early 1980s, scientists discovered that most of the genes in fruit flies that control the identity of different body parts -- a head, wing, or other structure -- are remarkably identical. The genes contain short sequences of deoxyribonucleic acid (DNA), which is found in every living cell and forms the "blueprint" for all organisms. Surprisingly, researchers discovered that the DNA sequence they had found in flies, called the homeobox, was common to genes that direct development of body structure in virtually all animals, including worms, flies, birds, mice and humans. "Homeo" is derived from the Greek word for similar; "box" refers to the clearly defined sequence, as though in a box.

Since the homeobox sequence stayed very similar during millions of years of evolution in many species, scientists suspected it must be important to life. They soon learned that the part of the protein it encodes can bind to DNA in a way that turns other genes on and off.

Even more surprising, scientists found that many genes containing the homeobox sequence, called hox genes, are lined up in clusters along chromosomes -- large strands of genetic material -- in an order that parallels the body part they control. On a fly chromosome, hox genes closest to one end control formation of the head, while the next ones in line control the upper body. At the other end of the cluster are genes controlling abdomen formation. When all these genes work correctly, the proteins they produce act together to ensure that each organism's body parts are made in correct locations. Hox genes also control development of parts of the central nervous system, including different regions of the brain.

Researchers concluded that hox genes are "master regulators" for the organization of the body. When the function of one of these genes is changed due to a genetic mutation or other factor, the wrong body part will develop in a given place. A fly, for example might grow a leg in the middle of its head.

A brief note, all the genes which evolutionists call 'pathways' are from multi-cellular creatures which arose during the Cabmrian explosion. The Hox genes are obviously a necessary requirement for multi-cellular organisms, that such a universal set of genes could have arisen in such a short time to become the basis of just about all multi-cellular animals, and that they could serve as building blocks for future species functions, shows pretty well that they could not have arisen either at random or due to 'selection' but could only have arisen by design.

249 posted on 06/17/2003 7:29:33 PM PDT by gore3000 (Intelligent people do not believe in evolution.)
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