Actually that is entirely possible if not more. Sadly- most were wiped out centuries before their ancestors ever set eyes on "white men" because of the first initial contacts with Europeons that brought diseases they had no resistance to and which spread all throughout North and South America well in advance of the "white man". When the Spanish explored the Mississippi Delta they found the remnants of the "mound building" culture that had only a generation before been wiped out by small pox before they had ever seen a white man.