Practical for whom? For ourselves eventually, maybe. What about, is it desirable given non-infinite resources and other competing desires? Assuming no general reversion to barbarism (not a sure bet), I think we will eventually conquer the solar system. Beyond that is a helluva big leap and would require the whole human race to cooperate with a religious or quasi-religious devotion requiring unprecidented self denial.
That is barring the discovery of cheap interstellar teleportation requiring a complete overhaul of the laws of physics or some similar plot device :)
Suppose somewhere out there are a species fully our equals or superiors intellectually who happen to be marine invertibrates. Would they even ever know there is an "out there"?