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Body/soul relationship is one of eternal union of substances that was not meant to be broken in respect to human nature. The body's death is preceded by the death of the soul in its formerly perfect relationship to God. So humans are conceived in sin - their soul is dead to God as soon as a person is conceived. So when a person is 'born again' that person's soul becomes alive to God by God's grace and they receive Jesus Christ as Lord and Savior and begin to live lives of gratitude to Him for what He has done for them - saving them and preparing a place in Heaven for them in His Father's House. But the body is not "born again" and it dies. Yet the person was created by God to be a body/soul unity - not to be separated by death. So death intrudes and the body now must die like the soul had been dead to God - so the body continues to decay until it does die. Then the Lord, who died to save us both body and soul, raises up the dead body on the last day of history and the resurrection He causes brings my body and soul back together in perfect unity and in perfect harmony with God's will.

When is the soul created? Moreland in the Body and Soul book makes the point that Scripture teaches the body and soul are created by God at the same moment. So as the father and mother conceive a child together that child's body though tiny and microscopic and though not fully unfolded is also at that very moment united by God with the eternal soul.