Signs: (may include one or more, and may be different for each rat in the colony)
-Excessive sneezing
-Exophthalmos (abnormal protrusion - bulging of the eyes)
-Squinting, excessive blinking, eye rubbing
-Chromodachryorrhea (red tears, excessive porhyrins are secreted with tears)
-Swollen face and neck
-Lesions (damaged cell tissue) in the lacrimal duct may result in corneal drying with severe secondary ocular lesions (dry eyes, conjunctivitis, ulcers of the cornea, bleeding inside the eye).