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Eh, a nuclear submarine is a pretty small target, and barely is up out of the water even at a dock. To fly an airliner in it and get a direct hit, not a graze, would be quite difficult.

While I'm sure with a hit you'd destroy the sub I question whether anything would be done to the reactor. You've got a pressure hull designed for deep diving, then the reactor itself.

And even if the reactor was damaged I really question whether there's any significant airborne release of radiation that would be a threat to nearby cities, despite the sort of fevered fantasies about this sort of thing by people that don't know jack diddly squat about reactors or radiation.

And you'd probably have to specifically hit the REAR of the sub with the airliner to do so, which would be even harder.