If you're able to hit someone in the center of the chest with one of those rounds I am sure he will die. (You will probably not have hearing after the situation has ended and you have to buy a hearing aid for permanent ear damage.)
Rates as something you won’t be carrying;) Above the 44 Mag by about two times; but even that gun, unless you’re Dirty Harry, will not be something anyone will want to carry around - outside of using it as a ‘short rifle’ for hunting!
Beware, possible flame war.... That 454 300 grainer @1600 fps carries about 1800 fpe. It also may as well be a single shot - follow up shots with those BIG boys is problematic, especially trying to hit anything stationary, let alone moving. Even if you are shooting a bear at close range, hopefully you have a backup weapons guy or a backup plan!
By contrast, my 10mm w/180 SGDHP, out of a 3.8” Glock barrel, hits 1250 fps w/625 fpe. Difference being, I can have four empty cases in the air at the same time, on target @10 yds, That’s 720 cumulative grains of ‘bonded’ bullets bringing 2500 cumulative foot pounds of energy with them! That same combination, btw, has accounted for at least one boar hog @30 yds (two shots) and one coyote (one shot) @110 yds, verified by a range finder.
Said all that to say, shoot what you shoot best, and NEVER expect the bad guy to STOP with one shot! That Boston clown soaked up eight (8) 40 caliber rounds (police shooters) and failed to expire before his brother ran him over with a car!!