Set the long term goals first: "The stars our destination". Then figure out the platforms and steps needed to realize that goal.
Why worry about tinkering with human physiology, when all we need to spin ourselves around in a circle to make the illusion of gravity to prevent all those detrimental side effects. The use of genetic engineering to facilitate space travel for now is in the realm of science fiction. Part of the problem is that once a body is adapted to life in zero gee, they can't visit earth ever again. I think we need to build habitats we can survive in rather than building a better man to live in space.