Since science and reason are inherently agnostic, if practiced honestly,
why should anyone presume they are in conflict with spirituality?
Good question. However we see much presumption made in that regard, do we not? And it's my feeling that most of it comes from the materialist side, whose impatience with the incompleteness of their knowledge drives them to lash out a bit.
Without reason it is not possible to know anything. One is agnostic to the exact degree they repudiate or evade reason.
(Of course, you are probably using the word agnostic in the very narrow theological sense. I am not constrained by your narrow usage.)
Hank
Good point. One problem is when a mystic makes claims that conflict with what is actually observed.