I didn't think cooking shielded you from the 'bad' prion problem.(?)
That thought actually crossed my mind as I hit the Post button. Prions are the simplest known form of infectious agent, and, therefore, one would expect them to be the hardiest. They don't depend on RNA/DNA processes. They might survive cooking that would be plenty sufficient to destroy viruses and bacteria.
According to this reference, you'd need a pretty good pressure cooker. But even then, you'd better check with some high-powered scientists first. Prions are even harder to denature than typical proteins.