To: mamelukesabre
Among the chemokine receptors, CCR5 and CXCR4 are the main coreceptors for HIV entrance. There exists a mutation in the gene that codifies for the CCR5 molecule which confers a high degree of resistance to HIV infection in vitro and in vivo.
This mutation named 32 consists in a 32 base-pair deletion that encodes for a non-functional protein, and as a result it is not expressed in the cell membrane. Homozygous individuals for this mutation do not have any known immunologic or biologic alteration.
The 32 allele is present mainly in Caucasian population.
In the United States the frequency is 8% to 10% in white population but less than 1% in Afro-American individuals. There is also a very low frequency of the mutation among Caucasians in Asia (Pakistan and India) and it has not been reported in China, Japan or pure African population.
To: Neuromancer
Among the chemokine receptors, CCR5 and CXCR4 are the main coreceptors for HIV entrance. There exists a mutation in the gene that codifies for the CCR5 molecule which confers a high degree of resistance to HIV infection in vitro and in vivo. This mutation named 32 consists in a 32 base-pair deletion that encodes for a non-functional protein, and as a result it is not expressed in the cell membrane. Homozygous individuals for this mutation do not have any known immunologic or biologic alteration. The 32 allele is present mainly in Caucasian population. In the United States the frequency is 8% to 10% in white population but less than 1% in Afro-American individuals. There is also a very low frequency of the mutation among Caucasians in Asia (Pakistan and India) and it has not been reported in China, Japan or pure African population. Boy I wish you know-nothings would back up your vague generalities and unsupported theses with at least a shred of insight and a few facts to back your foggy reasoning!
just kidding :)
31 posted on
10/06/2002 9:30:58 PM PDT by
lafroste
To: Neuromancer
There exists a mutation in the gene that codifies for the CCR5 molecule... Codifies?
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