In his opening monologue Letterman set up a joke: "How bout Hillary Clinton?...Remember, we thought it was a joke?" At first the audience clapped, but the clapping was soon overcome by a growing chorus of hisses and boos.
Letterman joked: "Theyre saying already that maybe in 2004 she might run for President. So if you look at it in these terms, listen to this: Becoming the Senator from New York is the first very important step to the Clintons so they can become, perhaps, a two impeachment family."
And he told another about Hillary: "Theyre saying that Hillary has her eyes on the Oval Office for 2004 and Im thinking, well its too bad she didnt have her eyes on the Oval Office when Bill was nailing Monica."