Do most people in Latin America or Africa, or even the Pacific rim, know or care about the mideast. Maybe some, but not most, I think.
There's a great short story by Ray Bradbury. An American couple travel to Mexico, when they hear a radio report of nuclear war between the US and USSR. The husband screams about "the end of the world" and the need to return to the US. After he leaves, a Mexican peasant glances around, everything looks fine, and he wonders who was this crazy gringo screaming about the "end of the world."
The story is a parable about American tendency to imagine that anything that happens to them happens to "the world," or that most of the world is even aware of them.
I'm not a traveler, have not left the US since 1977 (I'm one of the many non-rich Republicans), but I think Bradbury likely hit on something.
Israel is so over-played in the US media. True, many are dying, but I'm sure many more (even per capita) are dying daily in hot spots across the globe. But we never hear of it. We think the US and Israel are the center of the world, and imagine that the world thinks likewise. I don't think they do. So I don't think that the "world is against the US and Israel."
And since I'm a libertarian, foreign non-interventionist, I don't think the US should be so closely "allied" to any nation. I wish we returned to out pre-1898 foreign policy (yes, it can be done!).