To which I say, I agree that he is a left-wing nut, but that does not make him wrong on the observation of an irreducible cell. James Shapiro says as much. And the prion explanation is a very valid observation that DNA is not the sole repository of biological activity. What is the biological advantage to a prion? In other words, it is evident that the disadvantageous form of the protein is the more stable structure or the good form would be able to reform the bad form into the good form which it apparently does not.