From the Woodbridge, NJ government home page:
In 1929, the first Safety Engineered Super Highway intersection was built at the intersection of US Rt. 1 and NJ Rt. 35 in Woodbridge. We believe this to be the first such intersection built in the United States or the world. It was known as the Woodbridge Cloverleaf. When the NJ Turnpike opened in 1951, it created the famous intersection with the Garden State Parkway in Woodbridge. (Known locally as the Spaghetti Bowl)
I wonder which highway was the first to get "Jersey barriers"? Maybe Route 22 or 17?
The nice feature of jughandles is that you have to turn right to turn left before you are close enough to the intersection to read the street signs.