The Supreme Court is the sole judge of what is Constitutional and what is not. Your question is irrelevant because the Supreme Court would never say it was okay with them to sell Maine into slavery becuase such an action is a clear violation of the 13th Amendment. The justices aren't stupid, you know.
I agree that Supreme Court justices are not stupid (well, usually they're not stupid). But you didn't answer the question. Is the Federal government (in its various manifestations) the sole judge of the limits of Federal power? If the Federal government embarks on a course that the people of a particular State finds insufferable (whatever that policy may be), is there no recourse, but to accept it?
Respectfully,
D J White