Yes God does hold men repsonsible, but he holds women responsible as well. And I also would disagree that the wife doesn't ALWAYS respond in the most positive way. I can testify to that personally and I blame a lot on culture and this whole idea of 'finding yourself'. Listened to a sermon just today that a lot of the issues are brought upon by the fact that we have become a right here, right now world and the world culture is teaching that unless you're getting everything out of the relationship that you want(be it status, possessions, wealth, etc) then you not only have the right to leave, but the responsibility to leave and go find what makes you 'happy'. Interestingly enough, the sermon was 24 years old and is still true today.
A woman's responsibility for her husband and her family is outlined in Proverbs 31. However, nowhere does it say anything about "her" being responsible for the "relationship" itself.
And ... God clearly indicated who was responsible for the relationship when he ask Adam, "What have YOU done". After all, Adam was responsible for "tending" the garden - and Eve being deceived proved Adam was not doing his job.
If God was so concerned about the woman's responsibility, why didn't he ask Eve, "What have you done?" Surely God already knew what Eve had done? The fact that God did not inquire to Eve indicates God was placing responsibility upon Adam - whether he wanted it or not. And ... Adam only added insult to injury by insinuating it was God's fault ("it was that woman YOU gave me).